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KMID : 0381219750070120839
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Journal of RIMSK
1975 Volume.7 No. 12 p.839 ~ p.846
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Experimental Study of Acid Aspiration Pneumonia
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Abstract
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The object of the study was to determine the pH of fasting gastric juice and the efficacy of alkalizing action of sodium bicarbonate, and to examine morphologic changes in the lungs producing aspiration pneumonitis by intra-tracheal instillation.
First, the pH of fasting gastric juice in 49 adult person were analyzed and the effects of sodium bicarbonate on the pH level was studied in vivo and in vitro.
Second, seventy animals(70 rabbits) which grouped in 5 series, were studied. All series served to determine the severity of morphologic changes in the lungs by instillation of the buffer solution (pH 2 and pH 4), human gastric juice (pH 2 and pH 7), and denaturated and undersaturated HGJ (pH 3).
All animals were examined 48 hours, 72 hours, 1 week and 2 weeks after the procedures.
The results are: as follows:
1. The average mean value of pH in fasting gastric juice in normal adult was 2.33±0.67.
2. The effect of caffeine to the gastric secretion was not significant.
3. The neutralizing effects of sodium bicarbonate were marked. That is, the acidity of gastric juice was changed to pH 8.Q level without concern to the initial pH level. And this state was sustained over one hour in vivo.
4. Morphologic changes in the lungs were marked in 48 hours after instillation and the tissue reaction was more severe in higher acidity(pH 2-buffer solution and HGJ).
5. There were no differences between denaturated and undenaturated HGJ instillation groups in tissue reactions. But the inflammatory reaction was more prominant in undenaturated group.
6. Author recognized again that the human gastric juice was dangerous in developing of acid aspiration pneumonia(Mendelson´s syndrome) and suggest that gastric enzymes and microorganisms have little or no importance in the pathogenesis of acid aspirtion pneumonia.
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KEYWORD
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